Understanding What Receptors are Affected by TCA: A Pharmacological Deep Dive
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4 min read
Tricyclic antidepressants (TCAs) were among the first medications developed to treat depression, but their widespread use has been overshadowed by newer drugs with more targeted effects. A deeper understanding of what receptors are affected by TCA activity reveals a complex pharmacological profile responsible for both their therapeutic efficacy and their significant, often undesirable, side effects. This broad-spectrum action differentiates them from modern, more selective antidepressants.