Tag: Drug induced autoimmunity

Some studies suggest a link between depression and autoimmune diseases, with women diagnosed with depression having a higher subsequent risk for seronegative rheumatoid arthritis [1.6.3]. But can the treatment itself be a factor? The question of whether **can antidepressants trigger autoimmune disease** is complex, with evidence pointing towards immunomodulatory effects [1.7.7].

In the United States, drug-induced lupus erythematosus (DILE) accounts for an estimated 15,000 to 30,000 new cases of lupus each year [1.4.4, 1.4.6, 1.4.7]. Understanding what medications can trigger autoimmune diseases is crucial for patient safety and management.

While lupus anticoagulant (LA) is commonly associated with autoimmune conditions like systemic lupus erythematosus (SLE), over 100 drugs have been identified as potential triggers for a drug-induced lupus syndrome that can include the formation of this autoantibody. This can result in a paradoxical clotting abnormality that increases the risk of thrombosis. Understanding which medications cause lupus anticoagulant is crucial for both patients and clinicians in identifying and managing this rare complication.