Tag: Drug induced liver injury

Drug-Induced Liver Injury (DILI) is a leading cause of acute liver failure in the United States and a major reason for drug withdrawal from the market. The liver, a primary site for drug metabolism, is particularly susceptible to damage from various medications, which directly answers the question, 'Does ADRs affect the liver?'.

Over 1,000 medications and herbal products have been associated with drug-induced liver injury (DILI) [1.4.2]. While often considered safe for local use, the critical question remains: **can topical creams affect your liver** through systemic absorption? The answer is yes, though the risk varies.

Idiosyncratic drug-induced liver injury (iDILI) has an estimated incidence of 19 in 100,000 people, making it a leading cause of acute liver failure in developed countries [1.2.4]. This highlights the serious nature of these rare events, but **what is an example of an idiosyncratic drug effect** and why do they occur?

Adverse drug reactions (ADRs) are a significant public health issue, with some studies estimating they are the fourth leading cause of death in the US [1.6.3]. A rare and unpredictable type of ADR is an idiosyncratic event. So, **what is an example of an idiosyncratic event?** They range from severe skin reactions to organ failure [1.2.2, 1.2.3].

While drug-induced liver injury (DILI) is a known medical concern, affecting an estimated 14 to 19 per 100,000 people, the question remains: **can amlodipine cause liver damage?** This article examines the evidence on this widely prescribed medication.

While fenbendazole is known for a wide margin of safety in animals, reports show severe drug-induced liver injury in humans who take too much fenbendazole for unapproved, off-label uses. This highlights a crucial distinction in species-specific pharmacology and the serious dangers of self-medication with veterinary products.

While severe drug-induced liver injury (DILI) from antidepressants is rare, occurring in only 1.28–4 cases per 100,000 patient-years for many classes, all antidepressants have the potential to cause liver-related issues. Understanding **what antidepressants affect the liver** and monitoring for signs of liver dysfunction are crucial parts of patient care.

While severe drug-induced liver injury is estimated to occur in only 14 to 19 people per 100,000, it is a risk associated with many medications, including some for hypertension. The important question, "Can blood pressure meds affect liver function?" has a nuanced answer, as the risk varies significantly by drug class and individual factors.

In clinical trials, fewer than 2% of patients taking olmesartan experienced temporary elevations in liver enzymes, a rate comparable to placebo. While generally considered safe for the liver, the question remains: does olmesartan affect your liver in more significant ways?

While antihistamine-induced liver injury is rare, it is a risk to be aware of, particularly for those with pre-existing conditions. Understanding which antihistamine is best for your liver requires looking at how different classes of these drugs are metabolized and what precautions should be taken.