Tag: Drug likeness

First published in 1997, Lipinski's Rule of Five has since become a foundational principle in drug development, influencing how billions of dollars are spent in research. Understanding **why is Lipinski's rule important** is crucial for anyone in medicinal chemistry, as it helps predict a molecule's potential for oral bioavailability early in the discovery process.

A successful drug must possess a delicate balance of many, often conflicting, properties [1.5.5]. The 'drug octagon' is a conceptual framework that helps answer the question, 'What is the drug octagon?' by visualizing the eight critical parameters that medicinal chemists must optimize for a compound to become an effective medicine.