Tag: Drug safety

Severe, acute hepatic injury from the anesthetic halothane was rare, occurring in about 1 in 15,000 cases after initial exposure, yet significantly higher than modern agents. This established a historical benchmark for determining which of the following anesthetics drugs has a higher risk of causing hepatic toxicity.

The incidence of vancomycin-induced nephrotoxicity occurs in about 10% of patients receiving the drug at standard doses [1.2.1]. While a powerful antibiotic against MRSA, the question of **can vancomycin be nephrotoxic?** is a critical consideration in clinical practice.

The incidence of vancomycin-associated acute kidney injury (AKI) can range from 5% to 43% [1.4.5]. Understanding which of the following is most likely a side effect associated with vancomycin is crucial for patient safety and effective treatment.

In the late 1970s, reports of severe cardiotoxicity and fatal outcomes associated with bupivacaine led to an intense focus on understanding its pharmacological properties and developing safer alternatives. Levobupivacaine emerged as a safer option due to fundamental differences in its chemical structure, which significantly reduces the risk of cardiac adverse effects compared to the racemic bupivacaine mixture.

While local anesthetic systemic toxicity (LAST) is a rare but life-threatening complication, with an estimated occurrence of 7.5 to 20 per 10,000 peripheral nerve blocks, it can lead to cardiotoxicity. This article examines the critical question: Does lidocaine cause cardiotoxicity, exploring the conditions under which this risk arises and how it is managed safely?

Antacids can interfere with gastrointestinal drug absorption by either increasing or decreasing the rate at which a drug is absorbed, or the total quantity absorbed. This critical interaction means that Tums, a popular calcium carbonate antacid, can indeed affect medication absorption, potentially altering the effectiveness or safety of your other medications.

According to research published by the FDA, adverse drug reactions (ADRs) account for a significant number of hospitalizations and are a major healthcare concern. To better understand and manage these medication-related issues, pharmacists and other healthcare professionals classify them into distinct categories. This article will help you understand what are the four adverse drug reactions that healthcare professionals primarily categorize to ensure patient safety.

Adverse drug reactions (ADRs) are a significant public health issue, contributing to numerous emergency room visits and hospital admissions each year. Understanding what are the 10 adverse drug reactions can help both patients and healthcare providers better anticipate and manage these risks.

In a study of patients receiving care for acute coronary syndromes (ACS), 30.5% received Glyceryl Trinitrate (GTN) before their procedure [1.6.4]. As a cornerstone for managing angina, understanding its safety profile is critical. So, **what are the contraindications of GTN?**

More than 6 million prescriptions for diltiazem were filled in 2023, showing the widespread use of this class of drugs. However, understanding **why are calcium channel blockers contraindicated** in certain situations is crucial for patient safety and effective cardiovascular care.