Tag: Drug sales

In 2024, the global orphan drug market reached an estimated revenue of nearly $190 billion, illustrating the significant financial impact of these medications. This success raises the question: **What is the highest grossing orphan drug?** The answer is more complex than it appears, as many top sellers have expanded indications far beyond their initial orphan status.

In 2023, Americans spent nearly $38.6 billion on the diabetes and weight-loss drug semaglutide, making it the top-selling medication by consumer spending. The answer to what is America's best selling drug, however, depends on whether you measure by revenue, prescription volume, or a specific time frame, reflecting a dynamic and competitive market.

In 2024, Merck's immuno-oncology therapy Keytruda generated nearly $29.5 billion in sales, securing its position as the highest selling drug worldwide. The pharmaceutical landscape is highly dynamic, with new therapies and shifting demands constantly reshuffling the top ranks.

With global sales reaching nearly $29.5 billion in 2024, Merck's Keytruda has firmly held its position as the top earner in the pharmaceutical industry, making it the answer to the question: **What is the highest selling drug in the world?**. This cancer immunotherapy's continued success showcases the immense market power of advanced oncology treatments, especially as older blockbusters face new market dynamics.

For over a decade, Humira (adalimumab) dominated the pharmaceutical market, achieving peak annual sales of more than $20 billion, but its reign is over. Determining which is the most successful biologic drug requires examining metrics beyond just peak sales, considering factors like clinical impact, therapeutic area, and market longevity. This article explores the biggest names in biologics, comparing historical and recent successes.