Tag: Ehlers danlos syndrome

Failure rates for local anesthesia in general dental practice are estimated to be around 7%, with specific procedures like the inferior alveolar nerve block failing up to 10% of the time [1.9.4]. Understanding **in what circumstances may local anesthesia be less effective?** is crucial for both patients and clinicians.

The failure rate for local anesthesia is estimated to be between 5% and 15% [1.11.2]. Understanding **why do some people need more novocaine** involves exploring a combination of genetics, anxiety, and the specific physiological conditions of the tissue being treated [1.2.1].

The U.S. Food and Drug Administration (FDA) has issued warnings linking fluoroquinolone antibiotics to an increased risk of aortic rupture or dissection, particularly in patients with connective tissue disorders like Ehlers-Danlos syndrome (EDS). Given the fragile nature of connective tissue in EDS, understanding which medications pose a risk is a critical part of a comprehensive management strategy.