Understanding Sequential Blockade: Why Do We Give Thiazide Before Loop Diuretics?
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6 min read
For some patients with refractory fluid overload, standard high doses of loop diuretics become ineffective over time, a phenomenon known as diuretic resistance. To overcome this therapeutic hurdle, clinicians often turn to a combination strategy that includes a thiazide diuretic, leveraging a powerful pharmacological principle called sequential nephron blockade. Administering the thiazide first is a calculated step to maximize the synergistic effect of these two drug classes.
