Tag: Endocannabinoid system

A 2023 survey revealed that a significant portion of US adults have tried a CBD product, with many reporting positive effects such as reduced anxiety and improved sleep. For those who have experienced these benefits, the question of 'why do CBD gummies make me feel so good?' often arises, prompting a deeper look into the pharmacological mechanisms at play.

While CBD can enter the body through various methods, research suggests that standard topical CBD balms do not typically enter the bloodstream in significant amounts. This critical difference in how cannabinoids are absorbed is key to understanding why topicals provide localized, rather than systemic, effects.

First isolated in 2019 by Italian researchers, THCP binds to CB1 receptors with up to 33 times the affinity of Delta-9 THC. This discovery raises the question: Will THCP get you stoned? The answer is a definitive yes, with effects often reported as more intense and longer-lasting than traditional THC.

For decades, the exact mechanism of action for the common pain reliever Tylenol (acetaminophen) was not fully understood, particularly its impact on the brain. Recent discoveries have shed light on a multi-faceted approach involving the central nervous system, where the drug works to reduce pain and fever through interactions with several key neurochemical pathways.

In a survey of 135 CBD users, 30% reported experiencing dry mouth, making it a common side effect [1.7.1]. But why does CBD cause dry mouth? The answer lies in its complex interaction with the body's endocannabinoid system, which plays a key role in regulating saliva production [1.2.1, 1.2.2].

While cannabidiol (CBD) has long held the spotlight, cannabigerol (CBG) is gaining recognition for its therapeutic potential. Often called the “mother” cannabinoid, CBG is the precursor from which all other cannabinoids, including CBD, are synthesized. A closer look at what is CBG vs CBD reveals key distinctions in their effects and how they interact with the body.

While the cannabis plant produces over 100 different cannabinoids, the majority of research and consumer interest is focused on a handful of key compounds. This article breaks down what are the top 5 cannabinoids, exploring their unique properties and how they interact with the body's endocannabinoid system.

In the United States, nearly 34% of adults will experience an anxiety disorder at some point in their lives. This prevalence has led to a significant increase in interest surrounding alternative treatments, including whether **Does CBD help with fight or flight?** A growing body of scientific evidence from both preclinical and human studies suggests that cannabidiol may indeed play a modulating role in the body's stress response.

According to the CDC, over three out of five drug overdose deaths involve an opioid, illustrating the stark contrast in fatal overdose risk compared to cannabinoids. This critical difference between opioids and cannabinoids is one of many distinctions in their pharmacology, therapeutic applications, and potential for harm.

The cannabis plant contains over 60 natural cannabinoids, but it is primarily one chemical, tetrahydrocannabinol (THC), that gets you stoned by interacting with your body's endocannabinoid system. Understanding these complex interactions is crucial for navigating the effects of cannabis and other psychoactive substances.