Tag: Extrahepatic clearance

With total body clearance exceeding the generally accepted hepatic blood flow, propofol’s elimination involves more than just the liver. For clinicians and patients alike, understanding what organ clears propofol is essential for appreciating this anesthetic agent's rapid and predictable recovery profile.

Propofol's total body clearance rate is known to exceed total hepatic blood flow, suggesting that significant extrahepatic metabolism plays a crucial role in determining **how is propofol cleared**. This rapid and multi-organ clearance contributes to its short duration of action, making it a valuable anesthetic agent.