Tag: Fen phen

Reports from the 1990s linked the popular diet drug 'fen-phen' to valvular heart disease, bringing to light the critical question: what drugs cause heart valve damage?. This phenomenon, known as drug-induced valvular heart disease (DIVHD), can result from both prescribed and illicit substances that trigger fibrotic changes or infection in the heart valves.

In the late 1990s, medical reports highlighted an undeniable link between the diet drug combination fenfluramine-phentermine (Fen-phen) and heart valve disease, leading to its withdrawal. This revelation put a spotlight on the question: **What medications cause aortic stenosis** and other cardiac valve damage? While Fen-phen and similar drugs are off the market, other medications that interact with serotonergic pathways remain a concern for causing drug-induced valvular heart disease.

In 1997, the weight-loss combination drug known as "fen-phen" was voluntarily withdrawn from the market after a direct association with heart valve damage was identified. This event highlighted the serious cardiac risks of certain medications and raised awareness about **what drugs cause mitral valve disease** through specific receptor interactions.

In 1997, the U.S. Food and Drug Administration (FDA) requested the withdrawal of fenfluramine from the market, a decision spurred by compelling evidence of serious cardiac risks. This critical event answers the question of **why was fenfluramine withdrawn**, fundamentally altering the landscape of weight-loss medication.