Tag: Fetal trimethadione syndrome

Developed in the mid-20th century, oxazolidinediones were once used to treat certain types of epilepsy, particularly absence seizures. However, due to severe and life-threatening side effects, these medications, such as trimethadione (Tridione) and paramethadione (Paradione), are no longer used in modern medicine. The story of these drugs highlights significant advancements in pharmaceutical safety and the understanding of drug toxicity.

Developed in the 1940s, oxazolidinedione drugs were among the first synthetic anticonvulsants used specifically to treat absence seizures, a form of epilepsy previously difficult to manage. They paved the way for modern, safer treatments but are now largely obsolete due to significant side effects.