Tag: Finerenone

In a study on heart failure patients, approximately 9% of men taking spironolactone developed gynecomastia or breast pain, a side effect tied to higher doses and increased treatment duration. For many men prescribed this medication, understanding the risk and potential management strategies is critical: will spironolactone cause gynecomastia, and what are the options if it does?

First-generation mineralocorticoid receptor antagonists (MRAs) like spironolactone have been in use since the 1960s, predating the approval of the non-steroidal finerenone in 2021. The core **difference between finerenone and spironolactone** lies in their chemical structure, which leads to varying selectivity for the mineralocorticoid receptor, tissue distribution, side effect profiles, and specific clinical applications.

Chronic kidney disease (CKD) affects more than 10% of adults worldwide, and hypertension is a major contributing factor [1.6.2]. So, what is the best blood pressure pill for kidney disease to manage this critical link between blood pressure and kidney health?