Tag: First in human

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Is Phase 1 Always First in Humans? Exploring the Nuances of Clinical Trials

Oct 14, 2025 •

4 min read

Less than 10% of drugs that enter clinical trials succeed and receive approval [1.4.4]. A critical question in this high-stakes process is, **is phase 1 always first in humans?** The answer is nuanced, with the emergence of exploratory Phase 0 studies.