Tag: First line drugs

Pyrazinamide, commonly abbreviated as Z, was introduced in the 1950s and dramatically improved tuberculosis (TB) treatment by enabling the shortening of standard therapy regimens. Its unique activity against specific bacterial populations, particularly those in acidic environments, makes it an indispensable component of modern short-course chemotherapy.

Tuberculosis (TB) remains one of the top ten causes of death worldwide. Effectively combating this infection requires a multi-pronged approach, and at the heart of the standard first-line regimen is the acronym HRZE. This article explains what HRZE stands for and how this combination of drugs is used to treat TB.