Tag: First line treatment

In 2022, U.S. healthcare professionals prescribed amoxicillin 49.8 million times, making it the most commonly prescribed oral antibiotic [1.10.1]. But why is amoxicillin the drug of choice for a vast range of bacterial infections? Its widespread use stems from its proven efficacy, safety, and broad-spectrum activity [1.2.3, 1.2.1].

Studies show that between half and two-thirds of patients with bipolar disorder respond well to lithium [1.6.5]. For over 70 years, it has been the gold standard treatment, so why is lithium the first-line for bipolar disorder? Its efficacy is rooted in its powerful mood-stabilizing, neuroprotective, and anti-suicidal properties [1.2.3, 1.2.7].

The Indian pharmaceutical market grew by 8.4% in fiscal year 2024-2025 [1.3.2]. But when asking, 'What is the drug of choice in India?', the answer is complex, depending on whether you mean sales, prescriptions, or approved first-line treatments for specific diseases.

An estimated 19.1% of U.S. adults have had an anxiety disorder in the past year, making it the most common mental health concern in the country [1.3.1, 1.3.2]. So, what is the first line treatment for anxiety? It often involves psychotherapy and specific antidepressant medications [1.2.2, 1.2.3].

According to a 2025 study in *Frontiers*, clinical bacterial isolates showed a 22% prevalence of azithromycin resistance, indicating a significant rise since the COVID-19 pandemic. This growing concern is a primary factor contributing to why azithromycin is no longer recommended as a routine, first-line therapy for many common infections, shifting its role in modern medicine.