Tag: Folate antagonist

First used in 1962, trimethoprim is an antibiotic primarily used for bladder infections [1.2.5]. The answer to 'Are trimethoprim antibiotics?' is yes, but its function and frequent combination with other drugs make it unique among antibacterial agents [1.2.3, 1.2.5].

Affecting about 1.5 million people in the U.S., rheumatoid arthritis is often treated with methotrexate. This brings up the key question: **Which class of drug is methotrexate?** It is classified as an antimetabolite and also functions as a disease-modifying antirheumatic drug (DMARD).

Originally known as amethopterin, methotrexate was first synthesized in the 1940s as a chemotherapy agent [1.2.1, 1.3.4]. This article explores the history and pharmacology of this essential medication, including the answer to 'What is the old name for methotrexate?'.