Tag: Folate supplementation

According to a Cochrane review, supplementing with folic or folinic acid can lead to a significant reduction in the incidence of gastrointestinal side effects and elevated liver enzymes for patients taking methotrexate. For this reason, many patients with autoimmune conditions are prescribed a folic acid supplement to take alongside their methotrexate therapy.

Methotrexate, a cornerstone treatment for various autoimmune conditions, can cause folate deficiency and significant side effects in up to 30% of users within the first year. This necessitates supplementation, but the question of **how much methylfolate with methotrexate** to take is complicated by a key difference in how these forms of folate interact with the medication.