Tag: Folinic acid

Between 7% and 30% of patients stop methotrexate therapy within the first year due to toxicity [1.2.3]. So, **what vitamin can reduce the toxicity of methotrexate?** The answer lies in forms of vitamin B9: folic acid and folinic acid.

Autism Spectrum Disorder (ASD) affects approximately 2% of children in the United States [1.3.7]. Amidst ongoing research for effective therapies, a key question has emerged: Is leucovorin a surprising autism treatment for a specific subset of these children? [1.3.7, 1.7.4]

Leucovorin is a reduced, active form of folate, while folic acid is a synthetic precursor that must be enzymatically converted in the body. This fundamental difference explains why use leucovorin instead of folic acid in critical clinical situations, such as counteracting the toxic effects of methotrexate therapy.

Leucovorin, a medication also known as folinic acid, is a crucial component in certain cancer treatments and can act as an antidote to the side effects of specific chemotherapies. A primary purpose of leucovorin is to protect healthy cells from harm during high-dose chemotherapy regimens.