Tag: Formulation factors

The first FDA-approved transdermal patch for motion sickness was released in 1979, marking the beginning of a now multibillion-dollar industry. The effectiveness of this non-invasive method hinges on many variables, and understanding the factors affecting transdermal drug delivery system (TDDS) success is crucial for both drug developers and patients. These factors are complex, interacting biological, chemical, and physical elements that influence how a medication permeates the skin's protective barrier and enters the bloodstream.

According to a review in *Current State and Future Perspectives on Gastroretentive Drug Delivery Systems*, multiple factors influence gastric retention time (GRT), a key determinant for the success of any gastroretentive drug delivery system (GRDDS). These systems are engineered to remain in the stomach for an extended period, requiring a nuanced understanding of numerous interacting variables to be effective.