Can Sirolimus be Given IV? Understanding Oral vs. Intravenous Formulations
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4 min read
The oral bioavailability of sirolimus is notably low and variable, leading many to believe that intravenous (IV) administration is not possible. However, in a significant development, a distinct protein-bound formulation of intravenous sirolimus was approved by the FDA in November 2021 for the treatment of a specific type of cancer, proving that yes, sirolimus can be given IV. This specialized IV use is distinctly different from the long-standing oral versions of the drug.
