Tag: Gabaergic drugs

According to the National Institutes of Health, many drugs used in clinical practice act as positive allosteric modulators of GABA receptors, causing sedative, anticonvulsant, and anxiolytic effects. The list of drugs that potentiate GABA is extensive and includes various classes of central nervous system depressants, each with distinct mechanisms of action and therapeutic uses. This article explores these medications in detail.

As the brain's principal inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) plays a critical role in calming the nervous system. Many psychoactive drugs, such as benzodiazepines and barbiturates, are designed to enhance this natural sedative effect to treat conditions like anxiety, insomnia, and seizures by mimicking GABA.