Tag: Gastrointestinal risks

Individuals with pre-existing gastritis are at a significantly higher risk for serious gastrointestinal (GI) complications, including ulcers and bleeding, when taking oral diclofenac or other non-steroidal anti-inflammatory drugs (NSAIDs). Understanding this risk is crucial for anyone with a history of stomach issues considering this medication.

According to the FDA, clindamycin has a boxed warning because it can cause severe colitis, a potentially fatal complication. The main risk with clindamycin is the overgrowth of the dangerous bacteria *Clostridioides difficile*, which can lead to life-threatening diarrhea and inflammation of the large intestine.

While major drug interaction databases report no direct interaction, taking amoxicillin and mefenamic acid together requires caution due to potential overlapping side effects, especially those impacting the gastrointestinal tract. Both medications can cause stomach issues, and combining them may increase this risk, so medical advice is essential.