Tag: Gender affirming therapy

The co-administration of estradiol and spironolactone is a well-established and common practice in modern medicine, particularly for feminizing gender-affirming hormone therapy (GAHT) and managing conditions like PCOS. This combination leverages the feminizing effects of estradiol while using spironolactone to counteract androgenic hormones.

Spironolactone is a well-known anti-androgen, and studies show a significant percentage of male patients on higher doses experience breast development, or gynecomastia. This has led to the common question: **Does spironolactone cause you to look more feminine?** and what specifically are the hormonal effects responsible for this transformation?