Tag: Gray baby syndrome

First approved by the FDA in 1949, chloramphenicol was a groundbreaking broad-spectrum antibiotic. However, due to its association with severe, life-threatening side effects, including fatal aplastic anemia, its use has been heavily restricted and is subject to stringent regulations. Today, the question, **'Is chloramphenicol FDA approved?'** requires a nuanced answer that reflects decades of evolving safety concerns and restrictions.

Chloramphenicol, sometimes known as Phenicol, is an antibiotic with a significant risk of severe adverse effects, with fatal aplastic anemia estimated to occur in up to 1 in 24,500 treatment courses. Therefore, it is critical to understand what are the side effects of Phenicol and why its use is strictly limited to serious, life-threatening infections when safer alternatives are not available or effective.

First isolated from the bacterium *Streptomyces venezuelae* in 1947, chloramphenicol was the first synthetic broad-spectrum antibiotic ever produced in bulk [1.11.1, 1.11.2, 1.11.3]. So, how does chloramphenicol work simple? It functions by halting the production of essential proteins that bacteria need to grow and multiply [1.5.3].

Gray baby syndrome is a type of circulatory collapse that can occur in premature and newborn infants associated with excessively high serum levels of chloramphenicol [1.2.1]. So, can chloramphenicol cause Gray's syndrome? Yes, it is a well-documented and life-threatening adverse reaction.

The most serious side effect of chloramphenicol is aplastic anemia, which is rare but sometimes fatal [1.4.6]. Due to its high toxicity, understanding **what are the contraindications of chloramphenicol?** is crucial before its use is considered [1.8.6].

First isolated in 1947, chloramphenicol was once celebrated as a powerful broad-spectrum antibiotic. However, a growing body of evidence linking the drug to rare but fatal side effects prompted severe regulatory restrictions, raising the question: Why is chloramphenicol banned in the USA?

Originally isolated in 1947 from the bacterium *Streptomyces venezuelae*, **what is chloramphenicol?** It is a powerful, broad-spectrum antibiotic whose systemic use is severely limited due to its potential for causing serious and sometimes fatal side effects, including aplastic anemia.

The most serious side effect of chloramphenicol is idiosyncratic aplastic anemia, a rare but often fatal condition that occurs in approximately 1 in 24,000 to 40,000 treatment courses [1.4.3, 1.2.4]. This article explores the significant human toxicities associated with this potent antibiotic.

The use of the antibiotic chloramphenicol is severely restricted due to its potential to cause severe and fatal adverse effects. One of the most dangerous conditions it can trigger is aplastic anemia, a rare and often deadly blood disorder.

First isolated from the bacterium *Streptomyces venezuelae* in 1947, chloramphenicol marked a milestone as the first synthetic antibiotic to be mass-produced [1.7.1, 1.7.3]. Understanding **what is the structure of chloramphenicol** is key to grasping its powerful but risky pharmacological profile.