Tag: H1 antagonist

While many first-generation antihistamines can cause drowsiness due to their broader actions, one compound, cyproheptadine, is uniquely potent for its anti-serotonin effect in addition to blocking histamine. This dual-action pharmacology sets it apart from more selective, modern antihistamines and gives it a specific—and often off-label—role in treating certain conditions.

Patented in 1969 and introduced into medical use in 1976, mequitazine is an H1 antagonist and anticholinergic of the phenothiazine chemical class used to treat allergies. This article explores what the drug mequitazine is used for, from managing allergic rhinitis to chronic urticaria, and how it compares to other antihistamines.