Tag: Hair cells

Aminoglycoside antibiotics cause some degree of permanent hearing loss in approximately 20% of patients, affecting the inner ear’s sensory hair cells that do not regenerate in mammals. A clear understanding of what hair cells are affected by aminoglycosides is crucial for mitigating this irreversible damage.

Aminoglycoside antibiotics cause irreversible hearing loss and balance problems in up to 10% of patients receiving these drugs intravenously. The intricate mechanism of aminoglycoside ototoxicity involves a cascade of damaging intracellular events that lead to the permanent destruction of sensory hair cells in the inner ear.

Aminoglycosides, potent antibiotics used worldwide, are a well-known cause of permanent hearing loss. The primary issue is ototoxicity, a damaging effect on the inner ear that reveals exactly what part of the ear do aminoglycosides affect and why the consequences can be so severe.