Tag: Histamine antagonist

While structurally related to tricyclic antidepressants, the drug pizotifen is not primarily an antidepressant but is most notably characterized as a serotonin and histamine antagonist. It is a unique compound whose class is best defined by its antagonistic actions rather than its structural similarities.

Pizotifen is a serotonin and tryptamine antagonist indicated for the prophylactic management of migraines. But what does pizotifen do to the brain to achieve this? Its actions involve modulating key neurotransmitters and affecting various brain functions, resulting in both its therapeutic effects and common side effects.