Tag: Hypericum perforatum

A 2004 study on rats found that sub-chronic treatment with St. John's Wort significantly reduced brain cortisol levels, directly challenging the notion that it might raise cortisol. The relationship between this popular herbal supplement and stress hormones is complex and not fully understood, requiring a detailed examination of current evidence.

Over 28 years ago, St. John's Wort was hyped in the media as "nature's Prozac," but the comparison is misleading. While both have shown efficacy for mild-to-moderate depression, their pharmacological mechanisms, safety profiles, and regulatory status are fundamentally different.