Tag: Hypertrophic obstructive cardiomyopathy

Affecting an estimated 1 in 500 people, Hypertrophic Cardiomyopathy (HCM) is a common genetic heart disease [1.6.1, 1.6.4]. Understanding **why are vasodilators contraindicated in HOCM** is critical for patient safety, as these drugs can dangerously worsen the condition.

The left ventricular outflow tract (LVOT) obstruction in Hypertrophic Obstructive Cardiomyopathy (HOCM) is highly dynamic and sensitive to changes in hemodynamics. While vasodilators are commonly used to treat high blood pressure, their use in HOCM can have the paradoxical effect of dangerously worsening the condition. Understanding this unique mechanism is critical for safe and effective patient management.