Tag: Hyperuricemia

An estimated 74% of patients with gout also have hypertension, and the medications used to treat high blood pressure can impact uric acid levels. This raises a critical question for many: **can valsartan cause gout** or worsen existing symptoms?

Affecting an estimated 3.9% of U.S. adults, or 8.3 million people, gout is a painful form of inflammatory arthritis [1.7.2]. Understanding potential triggers, including the answer to 'What supplements can trigger gout?', is key for management.

According to several medical and pharmaceutical sources, the combination of fenofibrate and losartan is generally not contraindicated but requires careful medical supervision due to a moderate drug interaction. This co-administration can be beneficial for patients with co-occurring conditions, but necessitates close monitoring by a healthcare provider to ensure safety and effectiveness.

According to the American College of Rheumatology, the combination of colchicine and allopurinol is often recommended and safe for managing gout, especially when initiating therapy. This dual-drug approach leverages different mechanisms to control uric acid levels while preventing painful gout flares.

Gout affects nearly 8.3 million individuals in the U.S. alone, making it the most common form of inflammatory arthritis [1.2.1]. As researchers seek better solutions, the crucial question for many is, **what is the newest treatment for gout?**

According to numerous clinical studies, an increase in serum uric acid levels, known as hyperuricemia, occurs in a significant percentage of patients—reported to be anywhere from 43% to 100%—who are treated with the tuberculosis drug pyrazinamide. While often asymptomatic, this rise in uric acid is the underlying cause of one of the most frequently reported symptomatic side effects: joint pain, or arthralgia.

Affecting over 9 million adults in the United States, gout is a painful inflammatory arthritis caused by an excess of uric acid. A key treatment strategy for managing gout is leveraging the **uricosuric effect of probenecid** to help the body excrete this excess uric acid through the kidneys.

Uricosuric medications are a class of drugs that work to increase the excretion of uric acid in the urine, effectively lowering blood uric acid levels. These agents are primarily used to treat hyperuricemia, the root cause of gout, in patients whose kidneys do not efficiently eliminate uric acid from the body.

According to the American College of Rheumatology, allopurinol is strongly recommended as the preferred first-line urate-lowering medication for all patients with gout. This is the primary reason why **allopurinol is preferred over probenecid**, marking a significant difference in how these two gout treatments are utilized.

Research has documented that ethambutol, a drug used to treat tuberculosis, can cause a significant rise in serum uric acid levels in a majority of treated patients. So, does ethambutol increase uric acid and what does this mean for patients during their treatment regimen?