Tag: Ic50

In pharmacology, the half-maximal inhibitory concentration (IC50) is a critical measure for assessing a drug's potency, representing the concentration required to inhibit a biological process by 50%. This value is fundamental to drug discovery and understanding inhibitory effectiveness. So, is high or low IC50 better for a medication?

An estimated 90% of drug candidates that enter clinical trials ultimately fail [1.8.2]. To improve success rates, researchers rely on key metrics like the half-maximal inhibitory concentration (IC50). So, what is the interpretation of IC50 values, and how does it guide drug discovery?

In chronic toxicity testing, the IC25 is a critical statistical calculation used to determine the concentration of a substance that causes a 25% reduction in a biological function like growth or reproduction [1.2.1, 1.2.2]. Understanding **what is IC25 toxicity** is fundamental in pharmacology and environmental science for assessing the subtle, long-term effects of chemicals.