Tag: Idiosyncratic reaction

Reported frequencies of idiosyncratic drug reactions can range from an upper limit of 5% to as low as 1 in 10,000 to 100,000 individuals, making them notoriously difficult to detect during drug development. This low incidence and unpredictability are key to understanding **what is the meaning of idiosyncratic reaction** in pharmacology.

Idiosyncratic drug reactions (IDRs) are a significant concern in medicine, with some estimates suggesting they account for 10-15% of all adverse drug reactions [1.4.2]. So, **what is an example of an idiosyncrasy?** A classic example is the severe skin reaction, Stevens-Johnson syndrome, triggered by certain medications [1.2.2].

Idiosyncratic drug-induced liver injury (iDILI) has an estimated incidence of 19 in 100,000 people, making it a leading cause of acute liver failure in developed countries [1.2.4]. This highlights the serious nature of these rare events, but **what is an example of an idiosyncratic drug effect** and why do they occur?