Tag: Incretin

According to the head-to-head SURMOUNT-5 clinical trial, participants on tirzepatide (Zepbound) experienced significantly greater weight loss, with an average reduction of 20.2% of body weight, compared to 13.7% for those on semaglutide (Wegovy). This evidence is key to understanding if Ozempic is more effective than tirzepatide, as the medications share active ingredients with their weight-loss counterparts.

In recent years, the U.S. has seen an increasing number of adults living with overweight or obesity. This has fueled a surge in interest for new pharmacotherapies, leading to a common question for patients: Are Zepbound and Mounjaro the same medication? Though both contain the identical active ingredient, their answer is nuanced, depending on their distinct FDA-approved indications.

Used for centuries as a traditional diabetes treatment, galegine from the French lilac plant led to the development of modern biguanides. Understanding what is a biguanide and dipeptidyl peptidase-4 inhibitor is crucial for those managing type 2 diabetes, as these two drug classes work through distinct mechanisms to help control blood sugar levels.

Mounjaro (tirzepatide) has a half-life of approximately five days, meaning it takes about 25 to 30 days for one shot of Mounjaro to be almost entirely cleared from the body. Understanding this timeline is crucial for managing your treatment, anticipating effects, and planning for procedures or potential discontinuation.

Unlike semaglutide, which functions as a single GLP-1 receptor agonist, tirzepatide is a dual-action medication that targets both the GLP-1 and GIP receptors. This fundamental difference in pharmacology is key to answering the question: **Is tirzepatide a GLP or semaglutide?**