Tag: Integrase

Over 90% of HIV-infected patients starting treatment now use regimens that contain an integrase strand transfer inhibitor. Understanding **what is the mechanism of integrase** is crucial for appreciating how these modern antiretroviral drugs effectively halt viral replication by preventing the virus from permanently altering the host cell's DNA.

First approved in 2007, integrase strand transfer inhibitors (INSTIs) have revolutionized HIV treatment, becoming a cornerstone of modern antiretroviral therapy regimens. These potent medications, like dolutegravir and bictegravir, work by targeting a critical step in the HIV life cycle, providing effective viral suppression.