Beyond the Dose: What is the Estimand Regimen? Explained as a Clinical Trial Framework
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3 min read
Since its formal adoption in 2019 via the ICH E9(R1) guideline addendum, the estimand framework has become central to clinical trial design. It is important to clarify that "Estimand regimen" is a misconception; an estimand is not a drug protocol but a precise statistical framework for defining the treatment effect a trial aims to measure.
