Tag: Irreversible maois

Explore our medication guides and pharmacology articles within this category.

Are MAOIs permanent? Understanding Irreversible vs. Reversible Inhibition

Oct 13, 2025 •

4 min read

First used in the 1950s, Monoamine Oxidase Inhibitors (MAOIs) were among the earliest antidepressants developed [1.7.1]. The answer to 'Are MAOIs permanent?' depends on the type, as some bind irreversibly to enzymes, requiring the body to create new ones over several weeks [1.3.5, 1.4.1].

Are MAOI Inhibitors Irreversible? Understanding the Different Types

Oct 13, 2025 •

5 min read

While some of the first monoamine oxidase inhibitors (MAOIs) developed were indeed irreversible, newer generations include both irreversible and reversible inhibitors. This crucial distinction impacts a medication's duration of effect, side-effect profile, and interaction risks with certain foods and other drugs.