Tag: Kratom side effects

The US Food and Drug Administration (FDA) has warned consumers not to use kratom due to the risk of serious adverse events, including substance use disorder, seizures, and liver toxicity. Understanding what are the long-term side effects of kratom is crucial for anyone considering or already using this unregulated substance.

According to reports, millions of Americans have used kratom, a substance derived from the *Mitragyna speciosa* tree. A rare but increasingly recognized cutaneous side effect associated with chronic, long-term kratom use is hyperpigmentation, a skin discoloration that can manifest as brown, gray, or blue-gray patches. These effects, documented in numerous case reports, highlight a potentially serious dermatological consequence of the unregulated substance.