Tag: Kratom

A 2010 study on isolated rat tissues determined that kratom's mechanism does not involve competitive antagonism of acetylcholine at the neuromuscular junction, directly addressing whether **does kratom block acetylcholine**. The effects are mediated through alternative pathways, highlighting the complexity of its pharmacological profile.

While kratom's primary active alkaloids are well-documented to act on opioid receptors, research indicates a more complex pharmacology that includes interactions with other brain systems. This broader activity has led many to question whether kratom hit GABA receptors, which regulate anxiety and sedation.

Kratom contains over 40 alkaloids, with mitragynine and 7-hydroxymitragynine being the most active [1.5.6]. The question of whether **is kratom serotonin or dopaminergic** is complex, as research shows it interacts with multiple neurotransmitter systems, not just one [1.2.2].

Scientific studies show that the mitragynine content in kratom can vary dramatically, with one study of commercially available products finding amounts ranging from 2.76 to 20.05 milligrams per gram of dried material. This wide range means there is no single answer to **how much mitragynine is in 1g of kratom**, making potency unpredictable for consumers.

According to reports, poison control center calls related to kratom exposure increased tenfold between 2010 and 2015, highlighting a pressing public health concern and prompting the critical question: is kava safer than kratom?. Both plant-based substances, often used for their psychoactive effects, carry distinct and significant safety profiles that consumers need to understand before use.

While often marketed as a natural remedy, kratom’s primary alkaloids, mitragynine and 7-hydroxymitragynine, exhibit both partial agonist and antagonist effects across different opioid receptors, making the question, 'Is kratom a partial opioid antagonist?' far more complex than it appears. Its pharmacology is uniquely multifaceted, behaving in some ways like an opioid and in others like a mood-enhancer.

Kratom's primary alkaloid, mitragynine, makes up about 66% of its total alkaloid content [1.4.6]. So, what is the metabolite of kratom? When ingested, mitragynine is converted in the liver into the more potent 7-hydroxymitragynine [1.4.1, 1.4.6].

According to a recent pilot study, individuals with kratom addiction showed differences in the parts of the brain that regulate dopamine, highlighting the substance's impact on neurochemistry. The question, **does kratom deplete dopamine**, has a more complex answer than a simple 'yes' or 'no' and depends heavily on dosage, duration, and frequency of use.

Feel Free, a popular herbal tonic, contains a blend of two different plant substances, and the question is feel free kava or kratom? In reality, it includes both, making it a complex and controversial product. Due to its formulation, the product combines the relaxing effects of kava with the stimulant and opioid-like effects of kratom, leading to a unique and potentially risky psychoactive experience.

Yes, Kavasutra has a history of selling kratom in addition to kava, a practice openly advertised on its social media and corroborated by customer reviews. Many modern kava bars, including Kavasutra, have expanded their menus to offer a wider array of herbal products, directly answering the question: 'Does kavasutra have kratom?'.