Tag: Lariocidin

With projections estimating 10 million deaths annually by 2050 due to antimicrobial resistance (AMR), the discovery of new antibiotics is a global health priority [1.6.2]. **What is lariocidin?** It is a novel, naturally occurring lasso peptide antibiotic with a unique structure and mechanism for combating multidrug-resistant (MDR) pathogens [1.2.2, 1.3.6].

According to a 2022 analysis in *The Lancet*, antimicrobial resistance was directly responsible for 1.3 million deaths worldwide in 2019, highlighting the urgent need for new treatments. In response to this crisis, the most recently discovered antibiotic, lariocidin, a novel lasso-shaped peptide, was announced in March 2025, offering a unique mechanism against drug-resistant bacteria. This breakthrough, alongside new FDA approvals like gepotidacin, represents a crucial step forward in combating infectious diseases.