Is bupivacaine or lidocaine more cardiotoxic? A comparative analysis
•
4 min read
Pharmacological studies and clinical evidence consistently demonstrate that bupivacaine is significantly more cardiotoxic than lidocaine, with its higher potency and different binding kinetics on cardiac sodium channels contributing to its increased risk. The distinction between these two commonly used local anesthetics is critical for anesthesiologists and other healthcare providers to manage local anesthetic systemic toxicity (LAST) effectively.
