Tag: Lipid emulsion therapy

Of all local anesthetics, bupivacaine is associated with the highest incidence of cardiac toxicity and is among the most challenging to treat in cases of systemic toxicity [1.2.1, 1.2.3, 1.2.6]. This article explores which local anesthetic drug has the highest cardiotoxicity and why.

Intravenous lipid emulsion (ILE) therapy is a critical antidote for local anesthetic systemic toxicity (LAST), a rare but potentially fatal complication of regional anesthesia [1.4.7]. Understanding what are the contraindications for lipid emulsion therapy is essential for its safe and effective administration in emergency situations.

Although rare, local anesthetic systemic toxicity (LAST) can be a life-threatening complication, with an estimated incidence ranging from 7.5 to 20 per 10,000 peripheral nerve blocks. Knowing how to treat LAST toxicity with a rapid and coordinated response is critical for patient survival, centering on immediate intervention and specific resuscitation protocols.

Recent data suggests the incidence of Local Anesthetic Systemic Toxicity (LAST) is approximately 1 to 2 cases per 1,000 peripheral nerve blocks [1.7.1, 1.7.6]. Knowing **what are the symptoms of LA toxicity** is crucial for rapid identification and management of this life-threatening event.