Is methadone contraindicated in liver disease? A closer look at pharmacology and safety
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5 min read
Reports indicate that methadone can be used in patients across different stages of chronic liver disease, including cirrhosis, without worsening the underlying condition. This does not mean, however, that the medication is without risk, especially regarding how its metabolism is affected when liver function is impaired. So, **is methadone contraindicated in liver disease?** The answer is complex and depends heavily on the severity of the hepatic impairment.