Does vancomycin penetrate the bone? Systemic vs. Local Delivery
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5 min read
Several studies indicate that systemically administered vancomycin penetrates poorly into bone, particularly dense cortical bone. This raises significant questions about whether intravenous vancomycin can achieve sufficient concentrations at the infection site to combat severe bone infections like methicillin-resistant *Staphylococcus aureus* (MRSA) osteomyelitis.
