Tag: Long term antihistamine use

In May 2025, the U.S. Food and Drug Administration (FDA) issued a warning about a rare but severe itching, or pruritus, that can occur when discontinuing long-term use of certain oral allergy medicines, particularly cetirizine (Zyrtec) and levocetirizine (Xyzal). While dependence is uncommon, individuals who use antihistamines daily for extended periods may experience withdrawal symptoms upon stopping, and understanding **how long does antihistamine withdrawal take** is crucial for managing this process safely and effectively.

According to a 2018 study, over one in five Americans experiences seasonal allergic rhinitis, commonly treated with antihistamines. For some, questions arise regarding side effects, specifically: **can too much antihistamine cause joint pain**? While joint pain is not a primary symptom of overdose, certain types of antihistamines list it as a potential, albeit uncommon, side effect.