Tag: Major depressive disorder

Originally approved by the FDA in 2013, Trintellix has been prescribed to over 2 million patients in the United States. This medication, with the active ingredient vortioxetine, has a unique mechanism of action that sets it apart from other antidepressants, and this article will explain what kind of medication is Trintellix and its pharmacological profile.

According to recent studies, the antidepressant efficacy of trazodone is achieved at levels significantly higher than those typically used for insomnia. This distinction is crucial for patients asking, "How much trazodone for depression?", as the drug's effects are influenced by the amount administered.

In a 2022 study, over 64% of patients with Major Depressive Disorder (MDD) were considered 'not at all ill or borderline ill' after 3 months of Trintellix treatment [1.11.3]. This article addresses the key question: how do you feel when you start taking Trintellix?

With over 29 million prescriptions issued in the United States in 2021, bupropion is a widely used antidepressant [1.9.2]. The question for many is, **can bupropion be taken lifelong**? For chronic conditions like recurrent depression, long-term maintenance therapy is often necessary [1.4.1, 1.4.3].

In 2021, an estimated 21 million adults in the United States, or 8.3% of the adult population, had at least one major depressive episode [1.5.1]. The crucial question for many is, **which drugs treat depression most successfully?** This article examines the evidence.

While major depressive disorder affects millions in Europe, the antidepressant Pristiq is notably absent from the EU-wide market. Contrary to common belief, the answer to 'Why is Pristiq banned in Europe?' is that it isn't—its market application was voluntarily withdrawn by the manufacturer [1.4.1].

In clinical studies, between 1% and 10% of people taking Trintellix reported insomnia as a side effect [1.7.2]. The question of *does Trintellix make you sleepy or awake* is complex, as its effects can vary significantly among individuals.

Approximately 30% of people with major depressive disorder (MDD) have treatment-resistant depression, where standard antidepressants are not fully effective. For these individuals, the answer to the question 'Is Abilify a mood stabilizer or antidepressant?' becomes critical as it's often used as an adjunctive treatment.

Nausea is the most common side effect of Trintellix, affecting up to 32% of people in clinical studies [1.5.4]. A key question for many users is: is it better to take Trintellix at night or in the morning to manage this and other effects?

According to the FDA label for Trintellix (vortioxetine), its dose should be reduced by half when co-administered with a strong CYP2D6 inhibitor like bupropion. This crucial adjustment is necessary to prevent elevated Trintellix concentrations in the body, which can increase the risk of side effects. While this combination is possible, it requires careful medical supervision and dose management to be used safely.