Why is it so hard to get off prednisone? Understanding adrenal suppression
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4 min read
According to the Mayo Clinic, if you take prednisone for more than a few weeks, your adrenal glands decrease natural cortisol production, making it hard to get off prednisone and requiring a slow, medically-supervised tapering process. This critical biological effect is the primary reason for withdrawal symptoms and the need for careful management.
