Tag: Mef genes

Macrolide resistance among *Streptococcus pneumoniae*, a major cause of community-acquired pneumonia, has escalated at alarming rates globally, with one U.S. study reporting a resistance rate of 39.5%. Understanding **what is the most common mechanism of macrolide resistance** is crucial for developing new treatment strategies and combating this persistent public health threat.

The most clinically significant mechanism of macrolide resistance involves enzymes encoded by *erm* (erythromycin ribosome methylase) genes [1.4.1]. This article details which enzyme is responsible for macrolide resistance and explores other contributing biochemical pathways.