Tag: Melphalan

Alkylating agents were among the first effective anti-cancer drugs developed, with the first approved agent, mechlorethamine, stemming from military research in the 1940s. This broad class of chemotherapy includes numerous medications, raising the common question, “Which drug is an alkylator?”. These powerful medications function by damaging the DNA of cancer cells, preventing them from replicating and leading to their death, but their use requires careful management due to potential side effects.

Up to 90% of metastatic uveal melanoma cases are concentrated within the liver, making liver-directed therapy a critical need. **What is Hepzato?** It represents a significant advancement, offering a targeted chemotherapy delivery system to treat these unresectable liver metastases while minimizing the systemic exposure and side effects typically associated with traditional treatments.