Tag: Metabolic acidosis

In the United States, over 18,000 cases involving aspirin were reported to poison centers in 2021 [1.5.2]. Contrary to a simple answer, an aspirin overdose causes both acidosis and alkalosis in a phased and complex disturbance [1.2.3].

In the United States, over 20,000 cases of salicylate exposure are reported annually [1.8.3]. Knowing what to monitor for aspirin overdose is critical for managing this potentially life-threatening emergency, focusing on key clinical and laboratory markers.

While metformin is a highly effective and widely used medication for type 2 diabetes, the risk of metformin-associated lactic acidosis (MALA) is a rare but serious adverse event, with an incidence of about 5 cases per 100,000 in one analysis. This condition is primarily caused by a dual mechanism involving increased lactate production and reduced lactate clearance, especially when metformin accumulates in the body.

Named after pediatrician Alexis Hartmann, who modified the original Ringer's solution in the 1930s by adding lactate, Hartmann's fluid is a staple in medical settings for intravenous fluid therapy. This article explains what are the components of Hartmann's fluid and its clinical significance.

Acetazolamide's diuretic effect is notably self-limiting, often ceasing after only a few days of continuous use. This phenomenon, explained by its mechanism as a carbonic anhydrase inhibitor and the body's compensatory responses, is crucial for understanding **why is acetazolamide self-limiting** and why it is not used as a primary long-term diuretic therapy.

According to a 2025 analysis, combining acetazolamide and NSAIDs like ibuprofen creates a synergistic nephrotoxic effect, significantly increasing the risk of acute kidney injury. This critical interaction means the question, 'Can you take ibuprofen with acetazolamide?', should be approached with extreme caution and clear medical guidance.

Carbonic anhydrases are a ubiquitous family of metalloenzymes found in nearly every organ of the body, and medications that target them are vital for treating several conditions. Understanding **what is the mechanism of action of carbonic anhydrase inhibitors** reveals how these drugs can have wide-ranging effects on fluid and electrolyte balance in the body.

Up to 100% of patients in some studies report side effects like fatigue when taking acetazolamide, which can significantly impact a person's quality of life. So, **why does acetazolamide make me so tired**, and what are the specific physiological changes that cause this profound exhaustion?

Though relatively rare, the use of acetazolamide has been associated with severe and life-threatening adverse effects. Understanding **what is the most severe adverse effect of acetazolamide** is crucial for patient safety and requires awareness of conditions such as Stevens-Johnson syndrome, aplastic anemia, and liver injury.

According to the 2014 IIH Treatment Trial, patients on acetazolamide were at a significantly higher risk of experiencing loss of appetite compared to those on a placebo. The question, “Does acetazolamide suppress appetite?”, is a relevant inquiry for patients and healthcare providers alike, as this effect is a documented adverse reaction to the medication.